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Article

Ciprofloxacin selects for RNA polymerase mutations with pleiotropic antibiotic resistance effects.

The Journal of antimicrobial chemotherapy - 1 Jan 2017

Pietsch Franziska, Bergman Jessica M, Brandis Gerrit, Marcusson Linda L, Zorzet Anna, Huseby Douglas L, Hughes Diarmaid

Abstract excerpt

OBJECTIVES: Resistance to the fluoroquinolone drug ciprofloxacin is commonly linked to mutations that alter the drug target or increase drug efflux via the major AcrAB-TolC transporter. Very little is known about other mutations that might also reduce susceptibility to ciprofloxacin. We discovered that an Escherichia coli strain experimentally evolved for resistance to ciprofloxacin had acquired a mutation in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA-Directed RNA Polymerases

Share to Drug Resistance, Bacterial

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Share to Real-Time Polymerase Chain Reaction

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Share to Sequence Analysis, RNA

Source

Identifiers

PMID: 27621175
DOI: 10.1093/jac/dkw364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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