Efflux pump activity potentiates the evolution of antibiotic resistance across S. aureus isolates.

doi:10.1038/s41467-020-17735-y

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Article

Efflux pump activity potentiates the evolution of antibiotic resistance across S. aureus isolates.

Nature communications - 7 Aug 2020

Papkou Andrei, Hedge Jessica, Kapel Natalia, Young Bernadette, MacLean R Craig

Abstract excerpt

The rise of antibiotic resistance in many bacterial pathogens has been driven by the spread of a few successful strains, suggesting that some bacteria are genetically pre-disposed to evolving resistance. Here, we test this hypothesis by challenging a diverse set of 222 isolates of Staphylococcus aureus with the antibiotic ciprofloxacin in a large-scale evolution experiment. We find that a single efflux pump,...

Topics

Bacterial Proteins
Ciprofloxacin
Drug Resistance, Microbial
Evolution, Molecular
Gene Expression Regulation, Bacterial
Genome, Bacterial
Mutation
Phylogeny
Staphylococcus aureus
Transcriptome

Source

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Identifiers

PMID: 32769975
DOI: 10.1038/s41467-020-17735-y
PMCID: PMC7414891

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