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Article

Rare Synaptogenesis-Impairing Mutations in SLITRK5 Are Associated with Obsessive Compulsive Disorder.

PloS one - 1 Jan 2017

Song Minseok, Mathews Carol A, Stewart S Evelyn, Shmelkov Sergey V, Mezey Jason G, Rodriguez-Flores Juan L, Rasmussen Steven A, Britton Jennifer C, Oh Yong-Seok, Walkup John T, Lee Francis S, Glatt Charles E

Abstract excerpt

Obsessive compulsive disorder (OCD) is substantially heritable, but few molecular genetic risk factors have been identified. Knockout mice lacking SLIT and NTRK-Like Family, Member 5 (SLITRK5) display OCD-like phenotypes including serotonin reuptake inhibitor-sensitive pathologic grooming, and corticostriatal dysfunction. Thus, mutations that impair SLITRK5 function may contribute to the genetic risk for OCD. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28085938
DOI: 10.1371/journal.pone.0169994
PMCID: PMC5234816

Genes

SLITRK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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