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Article

De Novo Damaging DNA Coding Mutations Are Associated With Obsessive-Compulsive Disorder and Overlap With Tourette's Disorder and Autism.

Biological psychiatry - 15 Jun 2020

Cappi Carolina, Oliphant Melody E, Péter Zsanett, Zai Gwyneth, Conceição do Rosário Maria, Sullivan Catherine A W, Gupta Abha R, Hoffman Ellen J, Virdee Manmeet, Olfson Emily, Abdallah Sarah B, Willsey A Jeremy, Shavitt Roseli G, Miguel Euripedes C, Kennedy James L, Richter Margaret A, Fernandez Thomas V

Abstract excerpt

BACKGROUND: Obsessive-compulsive disorder (OCD) is a debilitating neuropsychiatric disorder with a genetic risk component, yet identification of high-confidence risk genes has been challenging. In recent years, risk gene discovery in other complex psychiatric disorders has been achieved by studying rare de novo (DN) coding variants. METHODS: We performed whole-exome sequencing in 222 OCD parent-child trios (184...

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Identifiers

PMID: 31771860
DOI: 10.1016/j.biopsych.2019.09.029
PMCID: PMC7160031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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