Article

Evolutionary and functional data power search for obsessive-compulsive disorder genes

2017-02-09

Abstract excerpt

<h4>SUMMARY</h4> Obsessive-compulsive disorder (OCD) is a severe psychiatric disorder linked to abnormalities in the cortico-striatal circuit and in glutamate signaling. We sequenced coding and regulatory elements for 608 genes implicated in OCD from humans and two animal models (mouse and dog). Using a new method, PolyStrat, which prioritizes variants disrupting evolutionarily conserved, functional regions, we f...

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Literature Corpus work: 25f7740a-f179-5722-bb8c-a32e5bfc3de7
DOI: 10.1101/107193

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