Article

De novo damaging coding mutations are strongly associated with obsessive-compulsive disorder and overlap with autism

2017-09-21

Abstract excerpt

<h4>ABSTRACT</h4> Obsessive-compulsive disorder (OCD) is a debilitating developmental neuropsychiatric disorder with a genetic risk component, yet identification of high-confidence risk genes has been challenging. We performed whole-exome sequencing in 222 OCD parent-child trios (184 trios after quality control), finding strong evidence that de novo likely gene disrupting and predicted damaging missense variants...

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Literature Corpus work: 4dd16029-ea63-5ab2-b495-df7f1be8e220
DOI: 10.1101/127712

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