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Article

Advancements in the Understanding of the Genetics of Obsessive-Compulsive Disorder (OCD).

Current psychiatry reports - 31 Jul 2026

Doppenberg A Christelle, Cappi Carolina, Strom Nora I, Crowley James J, Nyholt Dale R, Mitchell Brittany L, Derks Eske M

Abstract excerpt

PURPOSE OF REVIEW: This review summarizes recent advances in the genetics of Obsessive-Compulsive Disorder (OCD), their contribution to understanding disorder biology, and implication for clinical translation. RECENT FINDINGS: Recent GWAS identified 30 genome-wide significant loci and prioritized 25 putatively causal genes. Rare variant studies implicated specific genes, including CHD8, CELSR3, SLITRK5, and...

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Source

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Identifiers

PMID: 42536245
DOI: 10.1007/s11920-026-01705-0
PMCID: PMC13428006

Genes

CELSR3
CHD8
QRICH1
SLITRK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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