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Article

Exome sequencing in obsessive-compulsive disorder reveals a burden of rare damaging coding variants.

Nature neuroscience - 1 Aug 2021

Halvorsen Mathew, Samuels Jack, Wang Ying, Greenberg Benjamin D, Fyer Abby J, McCracken James T, Geller Daniel A, Knowles James A, Zoghbi Anthony W, Pottinger Tess D, Grados Marco A, Riddle Mark A, Bienvenu O Joseph, Nestadt Paul S, Krasnow Janice, Goes Fernando S, Maher Brion, Nestadt Gerald, Goldstein David B

Abstract excerpt

Obsessive-compulsive disorder (OCD) affects 1-2% of the population, and, as with other complex neuropsychiatric disorders, it is thought that rare variation contributes to its genetic risk. In this study, we performed exome sequencing in the largest OCD cohort to date (1,313 total cases, consisting of 587 trios, 41 quartets and 644 singletons of affected individuals) and describe contributions to disease risk...

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PMID: 34183866
DOI: 10.1038/s41593-021-00876-8

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