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Article

Molecular profiling and genome-wide analysis based on somatic copy number alterations in advanced colorectal cancers.

Molecular carcinogenesis - 1 Mar 2018

Sugai Tamotsu, Takahashi Yayoi, Eizuka Makoto, Sugimoto Ryo, Fujita Yasuko, Habano Wataru, Otsuka Kouki, Sasaki Akira, Yamamoto Eiichiro, Matsumoto Takayuki, Suzuki Hiromu

Abstract excerpt

To characterize somatic alterations in colorectal cancer (CRC), we conducted a genome-scale analysis of 106 CRC specimens. We assessed comprehensive somatic copy number alterations (SCNAs) in these CRC specimens. In addition, we examined microsatellite instability (MSI; low and high), genetic mutations (KRAS, BRAF, TP53, and PIK3CA), and DNA methylation status (classified into low, intermediate, and high type)....

Topics

Adult
Aged
Aged, 80 and over
Colorectal Neoplasms
DNA Copy Number Variations
DNA Methylation
Female
Genome-Wide Association Study
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microsatellite Instability

Middle Aged

Mutation

Proto-Oncogene Proteins p21(ras)

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 29230882
DOI: 10.1002/mc.22769
PMCID: PMC5814737

Genes

KRAS
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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