Article
Association between genomic alterations and metastatic behavior of colorectal cancer identified by array-based comparative genomic hybridization.
Genes, chromosomes & cancer - 1 Feb 2013
Sawada Takeshi, Yamamoto Eiichiro, Suzuki Hiromu, Nojima Masanori, Maruyama Reo, Shioi Yoshihiro, Akasaka Risaburo, Kamimae Seiko, Harada Taku, Ashida Masami, Kai Masahiro, Adachi Yasushi, Yamamoto Hiroyuki, Imai Kohzoh, Toyota Minoru, Itoh Fumio, Sugai Tamotsu
Abstract excerpt
Colorectal cancers (CRCs) exhibit multiple genetic alterations, including allelic imbalances (copy number alterations, CNAs) at various chromosomal loci. In addition to genetic aberrations, DNA methylation also plays important roles in the development of CRC. To better understand the clinical relevance of these genetic and epigenetic abnormalities in CRC, we performed an integrative analysis of copy number...
Topics
- Aged
- Aged, 80 and over
- Chromosome Aberrations
- Class I Phosphatidylinositol 3-Kinases
- Cluster Analysis
- Colorectal Neoplasms
- Comparative Genomic Hybridization
- DNA Copy Number Variations