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Article

Characterization of sporadic colon cancer by patterns of genomic instability.

Cancer research - 1 Apr 2003

Goel Ajay, Arnold Christian N, Niedzwiecki Donna, Chang Dong K, Ricciardiello Luigi, Carethers John M, Dowell Jeannette M, Wasserman Linda, Compton Carolyn, Mayer Robert J, Bertagnolli Monica M, Boland C Richard

Abstract excerpt

Colorectal cancer (CRC) can progress through two pathways of genomic instability: chromosomal (CIN) and microsatellite instability (MSI). We hypothesized that these two pathways are not always independent and that some tumors therefore show a significant degree of overlap between these two mechanisms. We classified 209 high-risk stage II and stage III sporadic CRCs based on their MSI status, using a National...

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PMID: 12670912

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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