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Article

Mitochondrial respiratory dysfunction disturbs neuronal and cardiac lineage commitment of human iPSCs.

Cell death & disease - 12 Jan 2017

Yokota Mutsumi, Hatakeyama Hideyuki, Ono Yasuha, Kanazawa Miyuki, Goto Yu-Ichi

Abstract excerpt

Mitochondrial diseases are genetically heterogeneous and present a broad clinical spectrum among patients; in most cases, genetic determinants of mitochondrial diseases are heteroplasmic mitochondrial DNA (mtDNA) mutations. However, it is uncertain whether and how heteroplasmic mtDNA mutations affect particular cellular fate-determination processes, which are closely associated with the cell-type-specific...

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Identifiers

PMID: 28079893
DOI: 10.1038/cddis.2016.484
PMCID: PMC5386384

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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