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Gaining Insight into Mitochondrial Genetic Variation and Downstream Pathophysiology: What Can i(PSCs) Do?

Genes - 22 Oct 2021

Moreira Jesse D, Gopal Deepa M, Kotton Darrell N, Fetterman Jessica L

Abstract excerpt

Mitochondria are specialized organelles involved in energy production that have retained their own genome throughout evolutionary history. The mitochondrial genome (mtDNA) is maternally inherited and requires coordinated regulation with nuclear genes to produce functional enzyme complexes that drive energy production. Each mitochondrion contains 5-10 copies of mtDNA and consequently, each cell has several...

Topics

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DNA, Mitochondrial
Gene Editing
Genetic Heterogeneity
Genome, Mitochondrial
Heteroplasmy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Induced Pluripotent Stem Cells

Mitochondrial Diseases

Stem Cell Transplantation

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Identifiers

PMID: 34828274
DOI: 10.3390/genes12111668
PMCID: PMC8624338

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