Article
Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential.
Stem cell research & therapy - 7 Nov 2023
Meshrkey Fibi, Scheulin Kelly M, Littlejohn Christopher M, Stabach Joshua, Saikia Bibhuti, Thorat Vedant, Huang Yimin, LaFramboise Thomas, Lesnefsky Edward J, Rao Raj R, West Franklin D, Iyer Shilpa
Abstract excerpt
BACKGROUND: Human mitochondrial DNA mutations are associated with common to rare mitochondrial disorders, which are multisystemic with complex clinical pathologies. The pathologies of these diseases are poorly understood and have no FDA-approved treatments leading to symptom management. Leigh syndrome (LS) is a pediatric mitochondrial disorder that affects the central nervous system during early development and...
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