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Article

Melatonin alleviates oxidative stress induced damage in human iPSCs harboring mtDNA 3243A>G mutation via MAPK pathway.

Stem cell research & therapy - 10 Oct 2025

Pu Zhixin, Wang Peiwen, Wang Mengyao, Chen Yaxin, Zhu Yating, Jiao Yuan, Zou Weiwei, Yu Biao, Cheng Huiru, Liu Yajing, Cao Yunxia, Ji Dongmei, Liang Dan

Abstract excerpt

BACKGROUND: Mitochondrial diseases are a group of serious inherited multisystem disorders caused by mutations in mitochondrial DNA (mtDNA) or nuclear DNA and still have faced a significant challenge to therapy due to their complicated genotype-phenotype relationships and diverse clinical manifestations. Human induced pluripotent stem cell (hiPSC) offered novel opportunities for cell-based modeling mitochondrial...

Read the complete abstract on PubMed

Topics

Humans
Oxidative Stress
DNA, Mitochondrial
Melatonin
Hydrogen Peroxide
Induced Pluripotent Stem Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Apoptosis

MAP Kinase Signaling System

Mitochondria

Mutation

Cell Survival

Cell Line

Membrane Potential, Mitochondrial

Source

Open in PubMed Open full text

Identifiers

PMID: 41074211
DOI: 10.1186/s13287-025-04666-y
PMCID: PMC12512320

Genes

BAX
BCL2
CCK
MFN1

Provenance

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