Article
Mitochondrial Dysfunctions Contribute to Hypertrophic Cardiomyopathy in Patient iPSC-Derived Cardiomyocytes with MT-RNR2 Mutation.
Stem cell reports - 13 Mar 2018
Li Shishi, Pan Huaye, Tan Chao, Sun Yaping, Song Yanrui, Zhang Xuan, Yang Wei, Wang Xuexiang, Li Dan, Dai Yu, Ma Qiang, Xu Chenming, Zhu Xufen, Kang Lijun, Fu Yong, Xu Xuejun, Shu Jing, Zhou Naiming, Han Feng, Qin Dajiang, Huang Wendong, Liu Zhong, Yan Qingfeng
Abstract excerpt
Hypertrophic cardiomyopathy (HCM) is the most common cause of sudden cardiac death in young individuals. A potential role of mtDNA mutations in HCM is known. However, the underlying molecular mechanisms linking mtDNA mutations to HCM remain poorly understood due to lack of cell and animal models. Here, we generated induced pluripotent stem cell-derived cardiomyocytes (HCM-iPSC-CMs) from human patients in a...
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