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Article

Induced pluripotent stem cells: ex vivo models for human diseases due to mitochondrial DNA mutations.

Journal of biomedical science - 22 Sept 2023

Chen Chao, Guan Min-Xin

Abstract excerpt

Mitochondria are essential organelles for cellular metabolism and physiology in eukaryotic cells. Human mitochondria have their own genome (mtDNA), which is maternally inherited with 37 genes, encoding 13 polypeptides for oxidative phosphorylation, and 22 tRNAs and 2 rRNAs for translation. mtDNA mutations are associated with a wide spectrum of degenerative and neuromuscular diseases. However, the pathophysiology...

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Identifiers

PMID: 37737178
DOI: 10.1186/s12929-023-00967-7
PMCID: PMC10515435

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