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Modelling Mitochondrial Disease in Human Pluripotent Stem Cells: What Have We Learned?

International journal of molecular sciences - 20 Jul 2021

McKnight Cameron L, Low Yau Chung, Elliott David A, Thorburn David R, Frazier Ann E

Abstract excerpt

Mitochondrial diseases disrupt cellular energy production and are among the most complex group of inherited genetic disorders. Affecting approximately 1 in 5000 live births, they are both clinically and genetically heterogeneous, and can be highly tissue specific, but most often affect cell types with high energy demands in the brain, heart, and kidneys. There are currently no clinically validated treatment...

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Cell Differentiation
DNA, Mitochondrial
Mitochondria
Mitochondrial Diseases
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pluripotent Stem Cells

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PMID: 34299348
DOI: 10.3390/ijms22147730
PMCID: PMC8306397

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