Article
Modeling APC mutagenesis and familial adenomatous polyposis using human iPS cells.
PloS one - 1 Jan 2018
Sommer Cesar A, Capilla Amalia, Molina-Estevez Francisco J, Gianotti-Sommer Andreia, Skvir Nicholas, Caballero Ignacio, Chowdhury Sanjib, Mostoslavsky Gustavo
Abstract excerpt
Mutations in the gene Adenomatous Polyposis Coli or APC appear in most sporadic cases of colorectal cancer and it is the most frequent mutation causing hereditary Familial Adenomatous Polyposis. The detailed molecular mechanism by which APC mutations predispose to the development of colorectal cancer is not completely understood. This is in part due to the lack of accessibility to appropriate models that...
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