Article
Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jul 2011
Pant Vinod, Xiong Shunbin, Iwakuma Tomoo, Quintás-Cardama Alfonso, Lozano Guillermina
Abstract excerpt
Mdm2 and Mdm4 are homologous RING domain-containing proteins that negatively regulate the tumor suppressor p53 under physiological and stress conditions. The RING domain of Mdm2 encodes an E3-ubiquitin ligase that promotes p53 degradation. In addition, Mdm2 and Mdm4 interact through their respective RING domains. The in vivo significance of Mdm2-Mdm4 heterodimerization in regulation of p53 function is unknown. In...
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