Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mdm proteins: critical regulators of embryogenesis and homoeostasis

16 Jan 2017

Abstract excerpt

Mdm2 and Mdm4 are negative regulators of the tumor suppressor p53; hence, this relationship is the focus of many cancer related studies. A multitude of experiments across various developmental stages have been conducted to explore the tissue-specific roles of these proteins in the mouse. When Mdm2 or Mdm4 are deleted in the germline or specific tissues, they display different phenotypic defects, some of which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cancer Research and Treatments
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28093454
DOI: 10.1093/jmcb/mjx004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mdm proteins: critical regulators of embryogenesis and homoeostasisPMID 28093454Read ↗

Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability.Semantic proximity Read ↗

The role of MDM2 and MDM4 in breast cancer development and preventionSemantic proximity Read ↗

Distinct downstream targets manifest p53-dependent pathologies in mice.Semantic proximity Read ↗

Regulation of kidney development by the Mdm2/Mdm4–p53 axisSemantic proximity Read ↗

A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network.Semantic proximity Read ↗

Mdm2 and Mdm4 loss regulates distinct p53 activities.Semantic proximity Read ↗

Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development.Semantic proximity Read ↗

MDM2 beyond cancer: podoptosis, development, inflammation, and tissue regeneration.Semantic proximity Read ↗

Overexpression of mouse Mdm2 induces developmental phenotypes in Drosophila.Semantic proximity Read ↗

Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development.Semantic proximity Read ↗

Structure and function of MDM2 and MDM4 in health and diseaseSemantic proximity Read ↗

The long and the short of it: the MDM4 tail so farSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.