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Article

The p53-Mdm2 network in progenitor cell expansion during mouse postnatal development.

The Journal of pathology - 1 Dec 2007

Liu G, Terzian T, Xiong S, Van Pelt C S, Audiffred A, Box N F, Lozano G

Abstract excerpt

Mdm2, an E3 ubiquitin ligase, negatively regulates the tumour suppressor p53. Loss of Mdm2 in mice results in p53-dependent apoptosis and embryonic lethality. This phenotype was rescued by the p53(515C) allele, which encodes an apoptosis-deficient p53R172P protein. However, these mice died within 2 weeks of birth, due to a severe impairment of progenitor cell expansion during postnatal haematopoiesis and...

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Source

Identifiers

PMID: 17893884
DOI: 10.1002/path.2238

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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