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Article

Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development.

Molecular and cellular biology - 1 Aug 2007

Terzian Tamara, Wang Yongxing, Van Pelt Carolyn S, Box Neil F, Travis Elisabeth L, Lozano Guillermina

Abstract excerpt

The tumor suppressor p53 is inactivated by multiple mechanisms that include mutations of the p53 gene itself and increased levels of the p53 inhibitors MDM2 and MDM4. Mice lacking Mdm2 or Mdm4 exhibit embryo-lethal phenotypes that are completely rescued by concomitant deletion of p53. Here we sho...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17526734
DOI: 10.1128/MCB.00555-06
PMCID: PMC1952101

Genes

MDM2
MDM4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17526734-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development.PMID 17526734Read ↗

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53.Semantic proximity Read ↗

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