5-Hydroxymethylcytosine correlates with epigenetic regulatory mutations, but may not have prognostic value in predicting survival in normal karyotype acute myeloid leukemia.

doi:10.18632/oncotarget.14171

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Article

5-Hydroxymethylcytosine correlates with epigenetic regulatory mutations, but may not have prognostic value in predicting survival in normal karyotype acute myeloid leukemia.

Oncotarget - 31 Jan 2017

Ahn Jae-Sook, Kim Hyeoung-Joon, Kim Yeo-Kyeoung, Lee Seung-Shin, Ahn Seo-Yeon, Jung Sung-Hoon, Yang Deok-Hwan, Lee Je-Jung, Park Hee Jeong, Choi Seung Hyun, Jung Chul Won, Jang Jun-Ho, Kim Hee Je, Moon Joon Ho, Sohn Sang Kyun, Won Jong-Ho, Kim Sung-Hyun, Michael Szardenings, Minden Mark D, Kim Dennis Dong Hwan

Abstract excerpt

Stem cells display remarkably high levels of 5-hydroxymethylcytosine (5hmC). Both TET2 and IDH1/2 mutations can impair the production of 5hmC, thus decreasing 5hmC levels. TET2 or IDH1/2 mutations are commonly observed in acute myeloid leukemia (AML). However, the implications of 5hmC on survival in normal karyotype AML patients have not been fully evaluated. The 5hmC levels were analyzed in 375 patients using...

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Identifiers

PMID: 28039446
DOI: 10.18632/oncotarget.14171
PMCID: PMC5352402

Genes

IDH1
TET2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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