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Decreased 5-hydroxymethylcytosine levels are associated with TET2 mutation and unfavorable overall survival in myelodysplastic syndromes.

Leukemia & lymphoma - 1 Nov 2013

Liu Xiaoliu, Zhang Guangsen, Yi Yan, Xiao Le, Pei Minfei, Liu Sufang, Luo Yunya, Zhong Haiying, Xu Yunxiao, Zheng Wenli, Shen Jiankai

Abstract excerpt

The clinical significance and mechanisms of TET2 are not well defined in myeloid malignancies. We detected TET2 mutations and assayed its catalyzing conversion product 5-hydroxymethylcytosine (5-hmC) in 61 Chinese patients with MDS. Ten patients were identified to have TET2 mutations (16.4%). 5-hmC levels in patients with MDS with TET2 mutations were significantly lower than in those without mutations, and CD34+...

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Source

Identifiers

PMID: 23432690
DOI: 10.3109/10428194.2013.778408

Genes

TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Decreased 5-hydroxymethylcytosine levels are associated with TET2 mutation and unfavorable overall survival in myelodysplastic syndromes.PMID 23432690Read ↗

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