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Cell-free DNA 5-hydroxymethylcytosine is an emerging marker of acute myeloid leukemia

20 Jul 2022

Abstract excerpt

Aberrant changes in 5-hydroxymethylcytosine (5hmC) are a unique epigenetic feature in many cancers including acute myeloid leukemia (AML). However, genome-wide analysis of 5hmC in plasma cell-free DNA (cfDNA) remains unexploited in AML patients. We used a highly sensitive and robust nano-5hmC-Seal technology and profiled genome-wide 5hmC distribution in 239 plasma cfDNA samples from 103 AML patients and 81...

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PMID: 35859008
DOI: 10.1038/s41598-022-16685-3

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