Article
CD98 regulates vascular smooth muscle cell proliferation in atherosclerosis.
Atherosclerosis - 1 Jan 2017
Baumer Yvonne, McCurdy Sara, Alcala Martin, Mehta Nehal, Lee Bog-Hieu, Ginsberg Mark H, Boisvert William A
Abstract excerpt
BACKGROUND AND AIMS: Vascular smooth muscle cells (VSMC) migrate and proliferate to form a stabilizing fibrous cap that encapsulates atherosclerotic plaques. CD98 is a transmembrane protein made of two subunits, CD98 heavy chain (CD98hc) and one of six light chains, and is known to be involved in cell proliferation and survival. Because the influence of CD98hc on atherosclerosis development is unknown, our aim...
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