Article

Hcy regulates SIRT1-STAT3 phosphorylation by upregulating WWP2 expression and induce VSMCs proliferation, migration, and phenotypic switch.

2023-02-13

Abstract excerpt

<title>Abstract</title> <p>The proliferation, migration, and cellular morphology of vascular smooth muscle cells (VSMCs) play important roles in the pathogenesis of atherosclerosis (AS). Homocysteine (Hcy) is a sulfur-containing amino acid, which is an intermediate product of methionine metabolism. Hcy can induce proliferation, migration, and phenotypic switch of VSMCs, but details of these mechanisms are still u...

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Literature Corpus work: 44c78cd4-b30f-5bac-8945-8b5ac18a5f34
DOI: 10.21203/rs.3.rs-2560475/v1

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