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Article

Neutralization of S100A4 induces stabilization of atherosclerotic plaques: role of smooth muscle cells.

Cardiovascular research - 7 Jan 2022

Sakic Antonija, Chaabane Chiraz, Ambartsumian Noona, Klingelhöfer Jörg, Lemeille Sylvain, Kwak Brenda R, Grigorian Mariam, Bochaton-Piallat Marie-Luce

Abstract excerpt

AIMS: During atherosclerosis, smooth muscle cells (SMCs) accumulate in the intima where they switch from a contractile to a synthetic phenotype. From porcine coronary artery, we isolated spindle-shaped (S) SMCs exhibiting features of the contractile phenotype and rhomboid (R) SMCs typical of the synthetic phenotype. S100A4 was identified as a marker of R-SMCs in vitro and intimal SMCs, in pig and man. S100A4...

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Identifiers

PMID: 33135065
DOI: 10.1093/cvr/cvaa311
PMCID: PMC8752361

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