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Article

Membrane-Tethered Metalloproteinase Expressed by Vascular Smooth Muscle Cells Limits the Progression of Proliferative Atherosclerotic Lesions.

Journal of the American Heart Association - 22 Jul 2017

Barnes Richard H, Akama Takeshi, Öhman Miina K, Woo Moon-Sook, Bahr Julian, Weiss Stephen J, Eitzman Daniel T, Chun Tae-Hwa

Abstract excerpt

BACKGROUND: The MMP (matrix metalloproteinase) family plays diverse and critical roles in directing vascular wall remodeling in atherosclerosis. Unlike secreted-type MMPs, a member of the membrane-type MMP family, MT1-MMP (membrane-type 1 MMP; MMP14), mediates pericellular extracellular matrix degradation that is indispensable for maintaining physiological extracellular matrix homeostasis. However, given the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Knockout, ApoE

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Source

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Identifiers

PMID: 28735290
DOI: 10.1161/JAHA.116.003693
PMCID: PMC5586255

Genes

APOE
MMP14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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