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Bivariate genome-wide association study suggests that the DARC gene influences lean body mass and age at menarche.

Science China. Life sciences - 1 Jun 2012

Hai Rong, Zhang Lei, Pei Yufang, Zhao Lanjuan, Ran Shu, Han Yingying, Zhu Xuezhen, Shen Hui, Tian Qing, Deng Hongwen

Abstract excerpt

Lean body mass (LBM) and age at menarche (AAM) are two important complex traits for human health. The aim of this study was to identify pleiotropic genes for both traits using a powerful bivariate genome-wide association study (GWAS). Two studies, a discovery study and a replication study, were performed. In the discovery study, 909622 single nucleotide polymorphisms (SNPs) were genotyped in 801 unrelated female...

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PMID: 22744181
DOI: 10.1007/s11427-012-4327-6

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