Bivariate Genome-Wide Association Study Implicates ATP6V1G1 as a Novel Pleiotropic Locus Underlying Osteoporosis and Age at Menarche.

doi:10.1210/jc.2015-2095

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Article

Bivariate Genome-Wide Association Study Implicates ATP6V1G1 as a Novel Pleiotropic Locus Underlying Osteoporosis and Age at Menarche.

The Journal of clinical endocrinology and metabolism - 1 Nov 2015

Tan Li-Jun, Wang Zhuo-Er, Wu Ke-Hao, Chen Xiang-Ding, Zhu Hu, Lu Shan, Tian Qing, Liu Xiao-Gang, Papasian Christopher J, Deng Hong-Wen

Abstract excerpt

OBJECTIVE: Age at menarche (AAM) is determined by the overall duration of endocrine-tissue sex hormone exposure levels. Osteoporosis, the most common metabolic bone disease, is characterized primarily by reduced bone mineral density (BMD) and an increased risk of low trauma fractures. Bone was an endocrine organ regulating the synthesis and secretion of sex steroid hormones. The mutual dependence between bone and...

Topics

5' Untranslated Regions
Adolescent
Adolescent Development
Adult
Aged
Asian People
Bone Density
China
Female
Genetic Association Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Genome-Wide Association Study

Humans

Menarche

Middle Aged

Osteoporosis

Osteoporosis, Postmenopausal

Polymorphism, Single Nucleotide

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Identifiers

PMID: 26312577
DOI: 10.1210/jc.2015-2095
PMCID: PMC4702453

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