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Article

Mimicking the tumor microenvironment to regulate macrophage phenotype and assessing chemotherapeutic efficacy in embedded cancer cell/macrophage spheroid models.

Acta biomaterialia - 1 Mar 2017

Tevis Kristie M, Cecchi Ryan J, Colson Yolonda L, Grinstaff Mark W

Abstract excerpt

Tumor associated macrophages (TAMs) are critical stromal components intimately involved with the progression, invasion, and metastasis of cancer cells. To address the need for an in vitro system that mimics the clinical observations of TAM localizations and subsequent functional performance, a cancer cell/macrophage spheroid model is described. The central component of the model is a triple negative breast cancer...

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Identifiers

PMID: 28011141
DOI: 10.1016/j.actbio.2016.12.037
PMCID: PMC5316313

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EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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