Article

Fibroblast-derived thrombospondin-1 shapes macrophage polarization in advanced human co-culture models

2026-05-29

Abstract excerpt

<h4>Background</h4> Tumor-associated macrophages (TAMs) are key drivers of the immunosuppressive tumor microenvironment (TME), supporting tumor progression through diverse functions. However, mechanistic studies of TAM polarization remain limited by the lack of physiologically relevant human model systems that capture stromal-immune interactions and macrophage heterogeneity. <h4>Methods</h4> We established advan...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bfd46d16-88a1-5b48-8b97-8180854715dd
DOI: 10.64898/2026.05.28.728363

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Fibroblast-derived thrombospondin-1 shapes macrophage polarization in advanced human co-culture modelsDOI 10.64898/2026.05.28.728363Read

Facilitation of Tumor Stroma-Targeted Therapy: Model Difficulty and Co-Culture Organoid MethodSemantic proximity Read

Cancer-associated fibroblast-mediated immune evasion: molecular mechanisms of stromal-immune crosstalk in the tumor microenvironmentSemantic proximity Read

Mimicking tumor cell heterogeneity of colorectal cancer in a patient-derived organoid-fibroblast modelSemantic proximity Read

Mapping and modeling human colorectal carcinoma interactions with the tumor microenvironmentSemantic proximity Read

At the Interface of Tumor-Associated Macrophages and Fibroblasts: Immune-Suppressive Networks and Emerging Exploitable TargetsSemantic proximity Read

Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancerSemantic proximity Read

Cancer-associated fibroblasts as abettors of tumor progression at the crossroads of EMT and therapy resistanceSemantic proximity Read

Organoid modeling of tumor-associated macrophages reveals phagocytosis checkpoint blockade-induced conversion to an immunosuppressive SPP1+ phenotypeSemantic proximity Read

Mimicking Tumor Cell Heterogeneity of Colorectal Cancer in a Patient-derived Organoid-Fibroblast ModelSemantic proximity Read

3D Cancer Models: Depicting Cellular Crosstalk within the Tumour MicroenvironmentSemantic proximity Read

3D Model of the Early Melanoma Microenvironment Captures Macrophage Transition into a Tumor-Promoting PhenotypeSemantic proximity Read

Molecular and epigenetic ex vivo profiling of testis cancer-associated fibroblasts and their interaction with germ cell tumor cells and macrophagesSemantic proximity Read