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Article

Tumor-on-a-chip platform to interrogate the role of macrophages in tumor progression.

Integrative biology : quantitative biosciences from nano to macro - 30 Sept 2020

Bi Ye, Shirure Venktesh S, Liu Ruiyang, Cunningham Cassandra, Ding Li, Meacham J Mark, Goedegebuure S Peter, George Steven C, Fields Ryan C

Abstract excerpt

Tumor-infiltrating leukocytes, in particular macrophages, play an important role in tumor behavior and clinical outcome. The spectrum of macrophage subtypes ranges from antitumor 'M1'-type to protumor 'M2'-type macrophages. Tumor-associated macrophages (TAMs) typically display phenotypic features of both M1 and M2, and the population distribution is thought to be dynamic and evolves as the tumor progresses....

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Share to Lymphocytes, Tumor-Infiltrating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Inbred NOD

Share to Neovascularization, Pathologic

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Source

Open in PubMed Open full text

Identifiers

PMID: 32930334
DOI: 10.1093/intbio/zyaa017
PMCID: PMC7525664

Genes

CXCL10
CXCL11
CXCL9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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