Article

Targeting human M2 macrophages with antibodies in optimized 3D tumor spheroids

2025-09-18

Abstract excerpt

<h4>ABSTRACT</h4> Tumor microenvironment (TME) constituents, including tumor-associated macrophages (TAMs), are now well known to have a significant impact on tumor development. TAMs can be predominant cells in the TME, able to promote cancer cell proliferation, resistance to treatments and immunosuppression. Inactivating these TAMs in tumors by their depletion or their repolarization into a specific anti-tumor,...

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Literature Corpus work: 2fc7190a-beae-563a-bc21-3852c693efff
DOI: 10.1101/2025.09.16.676563

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