Article

Tumor-Associated EDA-FN-Enriched Matrix Instructs Macrophage Behavior

2026-05-18

Abstract excerpt

<h4>Introduction</h4> Cancer progression is driven not only by tumor cells but also by interactions between the extracellular matrix (ECM), stromal cells, and immune cells within the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are major drivers of ECM remodeling, assembling ECM with aberrant organization. Extra domain A fibronectin (EDA-FN), a cellular FN containing an extra type III domain...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 35a7a5d3-e500-566c-a3a3-7867d7b8eb38
DOI: 10.64898/2026.05.14.725237

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tumor-Associated EDA-FN-Enriched Matrix Instructs Macrophage BehaviorDOI 10.64898/2026.05.14.725237Read

Cancer Associated Fibroblasts: The Architects of Stroma RemodelingSemantic proximity Read

Shaping Up the Tumor Microenvironment With Cellular FibronectinSemantic proximity Read

The Extracellular Matrix: Composition, Function, Remodeling and Its Role in Tumorigenesis<i></i>Semantic proximity Read

3D Model of the Early Melanoma Microenvironment Captures Macrophage Transition into a Tumor-Promoting PhenotypeSemantic proximity Read

Collagen Density Modulates the Immunosuppressive Functions of Tumor-Associated MacrophagesSemantic proximity Read

Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatmentsSemantic proximity Read

The 3D Collagen Network as a Determinant of Tumor Progression and Drug Delivery Efficiency in Breast AdenocarcinomaSemantic proximity Read

The Extracellular Matrix: Its Composition, Function, Remodeling, and Role in TumorigenesisSemantic proximity Read

Fibrous Matrix Architecture-Dependent Activation of Fibroblasts with a Cancer-Associated Fibroblast-like Phenotype.Semantic proximity Read

Extracellular matrix educates an immunoregulatory tumor macrophage phenotype found in ovarian cancer metastasis.Semantic proximity Read

Engineering the Extracellular Matrix to Model the Evolving Tumor MicroenvironmentSemantic proximity Read

Breast cancer cells interact with tumor-derived extracellular matrix in a molecular subtype-specific mannerSemantic proximity Read