Article

Fibroblasts from metastatic sites induce broad-spectrum drug desensitization via modulation of mitochondrial priming

2017-10-02

Abstract excerpt

<h4>ABSTRACT</h4> Due to tumor heterogeneity, most believe that effective treatments should be tailored to the features of an individual tumor or tumor subclass. It is still unclear what information should be considered for optimal disease stratification, and most prior work focuses on tumor genomics. Here, we focus on the tumor micro-environment. Using a large-scale co-culture assay optimized to measure drug-ind...

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Literature Corpus work: 445785e9-a683-538d-ab01-4563ecb7ffa4
DOI: 10.1101/197376

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