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Modeling 3D Tumor Invasiveness to Modulate Macrophage Phenotype in a Human-Based Hydrogel Platform.

Macromolecular bioscience - 1 Nov 2024

Monteiro Cátia F, Almeida Catarina R, Custódio Catarina A, Mano João F

Abstract excerpt

The immune system is a pivotal player in determining tumor fate, contributing to the immunosuppressive microenvironment that supports tumor progression. Considering the emergence of biomaterials as promising platforms to mimic the tumor microenvironment, human platelet lysate (PLMA)-based hydrogel beads are proposed as 3D platforms to recapitulate the tumor milieu and recreate the synergistic tumor-macrophage...

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PMID: 38940700
DOI: 10.1002/mabi.202400227

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