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Article

The structure formed by inverted repeats in p53 response elements determines the transactivation activity of p53 protein.

Biochemical and biophysical research communications - 29 Jan 2017

Brázda Václav, Čechová Jana, Battistin Michele, Coufal Jan, Jagelská Eva B, Raimondi Ivan, Inga Alberto

Abstract excerpt

The TP53 gene is the most frequently mutated gene in human cancer and p53 protein plays a crucial role in gene expression and cancer protection. Its role is manifested by interactions with other proteins and DNA. p53 is a transcription factor that binds to DNA response elements (REs). Due to the palindromic nature of the consensus binding site, several p53-REs have the potential to form cruciform structures....

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Identifiers

PMID: 28007599
DOI: 10.1016/j.bbrc.2016.12.113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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