Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sequence analysis of p53 response-elements suggests multiple binding modes of the p53 tetramer to DNA targets

16 Apr 2007

Abstract excerpt

The p53 tetramer recognizes specifically a 20-bp DNA element. Here, we examined symmetries encoded in p53 response elements (p53REs). We analyzed base inversion correlations within the half-site, as well as in the full-site palindrome. We found that p53REs are not only direct repeats of half-sites; rather, two p53 half-sites couple to form a higher order 20 bp palindrome. The palindrome couplings between the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Genomics and Chromatin Dynamics
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17439973
DOI: 10.1093/nar/gkm192

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sequence analysis of p53 response-elements suggests multiple binding modes of the p53 tetramer to DNA targetsPMID 17439973Read ↗

Probing potential binding modes of the p53 tetramer to DNA based on the symmetries encoded in p53 response elements.Semantic proximity Read ↗

Impact of Alu repeats on the evolution of human p53 binding sitesSemantic proximity Read ↗

[Functional heterogeneity of p53-responsive elements].Semantic proximity Read ↗

Two p53 tetramers bind one consensus DNA response elementSemantic proximity Read ↗

Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53Semantic proximity Read ↗

Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code.Semantic proximity Read ↗

Redefining the p53 response element.Semantic proximity Read ↗

A tetranucleotide polymorphic microsatellite, located in the first intron of the tyrosine hydroxylase gene, acts as a transcription regulatory element in vitro.Semantic proximity Read ↗

DNA Bending Is Essential for the Site-specific Recognition of DNA Response Elements by the DNA Binding Domain of the Tumor Suppressor Protein p53Semantic proximity Read ↗

The structure formed by inverted repeats in p53 response elements determines the transactivation activity of p53 protein.Semantic proximity Read ↗

Regression based predictor for p53 transactivation.Semantic proximity Read ↗

Low-level p53 expression changes transactivation rules and reveals superactivating sequencesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.