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Two p53 tetramers bind one consensus DNA response element

31 Mar 2016

Abstract excerpt

p53 tumor suppressor is a transcription factor that controls cell cycle and genetic integrity. In response to genotoxic stress p53 activates DNA repair, cell cycle arrest, apoptosis or senescence, which are initiated via p53 binding to its specific DNA response elements (RE). The consensus p53 DNA RE consists of two decameric palindromic half-site sequences. Crystallographic studies have demonstrated that two...

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PMID: 27034469
DOI: 10.1093/nar/gkw215

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