Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.

Proceedings of the National Academy of Sciences of the United States of America - 11 Jan 2011

Melero Roberto, Rajagopalan Sridharan, Lázaro Melisa, Joerger Andreas C, Brandt Tobias, Veprintsev Dmitry B, Lasso Gorka, Gil David, Scheres Sjors H W, Carazo José María, Fersht Alan R, Valle Mikel

Abstract excerpt

The multidomain homotetrameric tumor suppressor p53 has two modes of binding dsDNA that are thought to be responsible for scanning and recognizing specific response elements (REs). The C termini bind nonspecifically to dsDNA. The four DNA-binding domains (DBDs) bind REs that have two symmetric 10...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alanine
Share to Cystine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescence Resonance Energy Transfer

Share to Genes, p53

Share to Microscopy, Electron

Share to Nucleic Acid Conformation

Share to Protein Structure, Quaternary

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 21178074
DOI: 10.1073/pnas.1015520107
PMCID: PMC3021029

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21178074-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.PMID 21178074Read ↗

Two p53 tetramers bind one consensus DNA response elementSemantic proximity Read ↗

Quaternary structure of the specific p53-DNA complex reveals the mechanism of p53 mutant dominance.Semantic proximity Read ↗

p53 Monitors replication fork regression by binding to "chickenfoot" intermediates.Semantic proximity Read ↗

High-Resolution Imaging of Human Cancer Proteins Using Microprocessor Materials.Semantic proximity Read ↗

Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.Semantic proximity Read ↗

Crystal structure of the mouse p53 core DNA-binding domain at 2.7 A resolution.Semantic proximity Read ↗

Isolation of Disease-relevant p53 for Cryo-Electron Microscopy AnalysisSemantic proximity Read ↗

Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53Semantic proximity Read ↗

New insights into p53 function from structural studies.Semantic proximity Read ↗

The disordered DNA-binding domain of p53 is indispensable for forming an encounter complex to and jumping along DNA.Semantic proximity Read ↗

Probing potential binding modes of the p53 tetramer to DNA based on the symmetries encoded in p53 response elements.Semantic proximity Read ↗

A stable human p53 heterotetramer based on constructive charge interactions within the tetramerization domain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.