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Article

Redefining the p53 response element.

Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2009

Wang Bei, Xiao Ziwei, Ren Ee Chee

Abstract excerpt

The tumor suppressor p53 is a master transcriptional regulator that affects a diverse range of cellular events. Surprisingly, even with >100 validated p53 response element (RE) sequences available, the effect of p53 binding on transcriptional behavior is seldom predictable and no functional rules have been described. Here, we report a systematic study on the role of specific nucleotides within the p53RE by using...

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Identifiers

PMID: 19597154
DOI: 10.1073/pnas.0903284106
PMCID: PMC2709670

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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