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Article

Analysis of sheep α-synuclein provides a molecular strategy for the reduction of fibrillation.

Biochimica et biophysica acta. Proteins and proteomics - 1 Mar 2017

Bickle Lungisa, Hopwood John J, Karageorgos Litsa

Abstract excerpt

Parkinson's disease (PD) presents with neuropathological inclusions called Lewy bodies, which are primarily composed of fibrillar α-synuclein. Recently, we characterized sheep with Gaucher disease and since GBA1 mutations represent the highest genetic risk factor for PD, we have investigated α-synuclein fibrillation in the sheep. Here we demonstrate that differences in six amino acid residues between sheep and...

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Source

Identifiers

PMID: 28007442
DOI: 10.1016/j.bbapap.2016.12.008

Genes

GBA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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