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Article

Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment.

Cell - 25 Jan 2008

Jelluma Nannette, Brenkman Arjan B, van den Broek Niels J F, Cruijsen Carin W A, van Osch Maria H J, Lens Susanne M A, Medema René H, Kops Geert J P L

Abstract excerpt

Maintenance of chromosomal stability relies on coordination between various processes that are critical for proper chromosome segregation in mitosis. Here we show that monopolar spindle 1 (Mps1) kinase, which is essential for the mitotic checkpoint, also controls correction of improper chromosome attachments. We report that Borealin/DasraB, a member of the complex that regulates the Aurora B kinase, is directly...

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Source

Identifiers

PMID: 18243099
DOI: 10.1016/j.cell.2007.11.046

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment.PMID 18243099Read ↗

Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.Semantic proximity Read ↗

MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components.Semantic proximity Read ↗

Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface.Semantic proximity Read ↗

Mps1 and Ipl1/Aurora B act sequentially to correctly orient chromosomes on the meiotic spindle of budding yeast.Semantic proximity Read ↗

Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis.Semantic proximity Read ↗

Chromosomal Instability by Inefficient Mps1 Auto-Activation Due to a Weakened Mitotic Checkpoint and Lagging ChromosomesSemantic proximity Read ↗

Mps1 phosphorylation of Dam1 couples kinetochores to microtubule plus ends at metaphase.Semantic proximity Read ↗

Delineating the contribution of Spc105-bound PP1 to spindle checkpoint silencing and kinetochore microtubule attachment regulation.Semantic proximity Read ↗

The phosphorylation of a kinetochore protein Dam1 by Aurora B/Ipl1 kinase promotes chromosome bipolar attachment in yeast.Semantic proximity Read ↗

CENP-E--dependent BubR1 autophosphorylation enhances chromosome alignment and the mitotic checkpoint.Semantic proximity Read ↗

Aurora-A phosphorylates Augmin complex component Hice1 protein at an N-terminal serine/threonine cluster to modulate its microtubule binding activity during spindle assembly.Semantic proximity Read ↗

Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1.Semantic proximity Read ↗

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