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Article

A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability.

Proceedings of the National Academy of Sciences of the United States of America - 18 Sept 2018

Sadler Jessica B A, Wenzel Dawn M, Strohacker Lauren K, Guindo-Martínez Marta, Alam Steven L, Mercader Josep M, Torrents David, Ullman Katharine S, Sundquist Wesley I, Martin-Serrano Juan

Abstract excerpt

Cytokinetic abscission facilitates the irreversible separation of daughter cells. This process requires the endosomal-sorting complexes required for transport (ESCRT) machinery and is tightly regulated by charged multivesicular body protein 4C (CHMP4C), an ESCRT-III subunit that engages the abscission checkpoint (NoCut) in response to mitotic problems such as persisting chromatin bridges within the midbody....

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Identifiers

PMID: 30181294
DOI: 10.1073/pnas.1805504115
PMCID: PMC6156662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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