Article
Hematopoietic arginase 1 deficiency results in decreased leukocytosis and increased foam cell formation but does not affect atherosclerosis.
Atherosclerosis - 1 Jan 2017
Ren Baoyan, Van Kampen Erik, Van Berkel Theo J C, Cruickshank Sheena M, Van Eck Miranda
Abstract excerpt
BACKGROUND AND AIMS: Arginase1 (Arg1), an M2 macrophage marker, plays a critical role in a number of immunological functions in macrophages, which are the main cell type facilitating atherosclerotic lesion development. Arg1 uses the substrate l-arginine to create l-ornithine, a precursor molecule required for collagen formation and vascular smooth muscle cell differentiation. By reducing l-arginine availability,...
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