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Article

Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1.

Cardiovascular research - 1 Nov 2017

Bhatta Anil, Yao Lin, Xu Zhimin, Toque Haroldo A, Chen Jijun, Atawia Reem T, Fouda Abdelrahman Y, Bagi Zsolt, Lucas Rudolf, Caldwell Ruth B, Caldwell Robert W

Abstract excerpt

AIMS: Elevation of arginase activity has been linked to vascular dysfunction in diabetes and hypertension by a mechanism involving decreased nitric oxide (NO) bioavailability due to L-arginine depletion. Excessive arginase activity also can drive L-arginine metabolism towards the production of ornithine, polyamines, and proline, promoting proliferation of vascular smooth muscle cells and collagen formation,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29048462
DOI: 10.1093/cvr/cvx164
PMCID: PMC6410953

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