Article
Molecular landscape and clonal architecture of adult myelodysplastic/myeloproliferative neoplasms.
Blood - 15 Oct 2020
Palomo Laura, Meggendorfer Manja, Hutter Stephan, Twardziok Sven, Ademà Vera, Fuhrmann Irene, Fuster-Tormo Francisco, Xicoy Blanca, Zamora Lurdes, Acha Pamela, Kerr Cassandra M, Kern Wolfgang, Maciejewski Jaroslaw P, Solé Francesc, Haferlach Claudia, Haferlach Torsten
Abstract excerpt
More than 90% of patients with myelodysplastic/myeloproliferative neoplasms (MDSs/MPNs) harbor somatic mutations in myeloid-related genes, but still, current diagnostic criteria do not include molecular data. We performed genome-wide sequencing techniques to characterize the mutational landscape of a large and clinically well-characterized cohort including 367 adults with MDS/MPN subtypes, including chronic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.